Cymbalta at 60 mg Dose Effective at Easing Pain of Fibromyalgia, Review Study Reports

Cymbalta at 60 mg Dose Effective at Easing Pain of Fibromyalgia, Review Study Reports
An approved medication, Cymbalta (duloxetine) is effective at easing pain in fibromyalgia (FM) patients, a large meta-analysis shows. A daily 60 mg dose is enough to trigger therapeutic benefits with a lesser risk side effects than is likely at higher doses. The study “Duloxetine for pain in fibromyalgia in adults: a systematic review and a meta – analysis” was published in the International Journal of Neuroscience. Although the mechanisms behind FM are not completely understood, the disease is known to be linked with problems in neurotransmitters — chemicals that transmit nervous signals — that play a role in processing pain and the response to stress. Cymbalta, originally indicated to treat depression, is also approved  in the U.S. and elsewhere to ease pain linked to fibromyalgia and promote overall well being. The medicine increases the levels of the neurotransmitters serotonin and norepinephrine that help relieve pain and depression. Its dose use in clinical practice ranges from 30 up to 120 milligrams (mg) a day. A team of researchers in China performed a systematic analysis of studies published from 2000 through March 2019 to evaluate the analgesic (pain-easing) efficacy of Cymbalta. They also assessed whether a dose of 60mg/day or 120mg/day of Cymbalta was most effective. The researchers analyzed data from seven clinical studies evaluating Cymbalta in a total of 2,
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