Analgesic Tapentadol Can Reduce Pain in Some Fibromyalgia Patients, Study Suggests

Analgesic Tapentadol Can Reduce Pain in Some Fibromyalgia Patients, Study Suggests
Tapentadol was shown to reduce pain in people with fibromyalgia. Normal cornea nerve fibers predicted this analgesic response, while patients with abnormal fibers had no response to this treatment. The study, titled "Cornea nerve fiber state determines analgesic response to tapentadol in fibromyalgia patients without effective endogenous pain modulation," was published in the European Journal of Pain. Tapentadol is an analgesic medication that works by affecting the opioid receptors, and the hormone noradrenaline, within the body. Its specific mechanism of action relies on improving "descending pain inhibition," which is experimentally measured by a technique called conditioned pain modulation (CPM). In essence, this is the concept that one stimulus can override another, creating the so-called "pain-inhibits-pain" effect. In this study, researchers assessed the effect of tapentadol on CPM. Fibromyalgia patients who were experiencing chronic pain were given either tapentadol (15 people) or a placebo (19 people) for three months. They were assessed monthly throughout the treatment, and also one month after treatment. CPM was measured via a test that involved, essentially, having
Subscribe or to access all post and page content.

Leave a Comment

Your email address will not be published. Required fields are marked *