Cymbalta More Effective than Lyrica for Fibromyalgia Pain, But with More Side Effects, Study Suggests

Cymbalta More Effective than Lyrica for Fibromyalgia Pain, But with More Side Effects, Study Suggests
Cymbalta (duloxetine) is more effective than Lyrica (pregabalin) for the treatment of chronic pain associated with fibromyalgia, but has a higher dropout rate due to adverse events, a study has found. The study, "Comparing duloxetine and pregabalin for treatment of pain and depression in women with fibromyalgia: an open-label randomized clinical trial," was published in the DARU Journal of Pharmaceutical Sciences. Fibromyalgia is characterized by widespread chronic pain that is often accompanied by anxiety, depression, sleep disorders, and fatigue. There are no specific therapies for this condition, so patients are often treated with medicines initially developed for other diseases. Cymbalta, an antidepressant, and Lyrica, an anti-epileptic, are two of the most commonly prescribed medications for the treatment of fibromyalgia. Both have been approved by the U.S Food and Drug Administration and Health Canada. Although the treatments have different modes of action, they are associated with a reduction in pain and depression as well as other mental symptoms. A team of researchers in Iran designed an open-label clinical trial to compare the efficacy and side effects of both therapies. They evaluated 99 fibromyalgia patients, between the ages of 18 and 65 years old, who were randomly assigned to take one of the therapies for four weeks. Patients had not received any of the medications for 12 weeks before the start of the study and had no other conditions that caused chronic pain. A total of 35 patients in the Cymbalta arm and 31 patients in the Lyrica arm finished the four-week trial and were included in the final results. The researchers compared the scores of the Widespread Pain Index (WPI) and Beck Depression Inventory-II of each pati
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