Mirogabalin May Help Lessen Neuropathic Pain in Fibromyalgia, Rat Study Shows

Mirogabalin May Help Lessen Neuropathic Pain in Fibromyalgia, Rat Study Shows
Mirogabalin besylate, a calcium channel blocker approved as a treatment for neuropathic pain in Japan and marketed under the brand name Tarlige, reduced pain scores in two rat models of fibromyalgia, a study shows. The study, “Analgesic effects of mirogabalin, a novel ligand for α2δ subunit of voltage-gated calcium channels, in experimental animal models of fibromyalgia,” was published in the journal Naunyn-Schmiedeberg's Archives of Pharmacology. Fibromyalgia is a chronic condition consisting of widespread pain and extreme sensitivity to mechanical stimulus-like pressure. Other symptoms including fatigue, sleep disturbances, and psychological disorders such as depression and anxiety are often linked to fibromyalgia. Although the exact cause of fibromyalgia is unclear, scientists believe that pain is not processed correctly at the brain level, leading to excessive sensitivity and pain perception. Neuropathic pain is the term used to describe the pain felt by a damaged nervous system. Due to its basis in neurological dysfunction, fibromyalgia can be studied in models that mimic pain caused by damage to the central or peripheral nervous system. In this study, researchers used two different rat models of fibromyalgia — the intermittent cold stress model (ICS) and the unilateral intramuscular acidic saline injection model (Sl
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