Fibromyalgia and Gastroesophageal Reflux Disease Are Linked, New Study Shows

Fibromyalgia and Gastroesophageal Reflux Disease Are Linked, New Study Shows

Fibromyalgia and gastroesophageal reflux disease (GERD) have a bidirectional association, a new population-based study in Taiwan shows.

The study, “Bidirectional association between fibromyalgia and gastroesophageal reflux disease: two population-based retrospective cohort analysis,” was published in the journal Pain.

The study’s senior author was Chia-Hung Kao, MD, a professor at the Graduate Institute of Clinical Medical Science and School of Medicine at the China Medical University in Taichung, Taiwan.

Patients with fibromyalgia have gastrointestinal disturbances including irritable bowel syndrome and GERD, which is characterized by gastric acid entering the esophagus, oral cavity, or the lungs, causing regurgitation and heartburn.

However, the mechanisms underlying this relationship are unclear, although animal studies have suggested that acidity in the esophagus may be a critical factor.

Patients with GERD frequently use proton pump inhibitors (PPIs) to decrease the production of gastric acid. But the long-term use of this group of drugs may alter susceptibility to bacterial pathogens in the gut and cause vitamin B12 and magnesium deficiencies, which are regarded as potential contributors to developing fibromyalgia.

In the other direction, fibromyalgia patients on PPIs for other gastrointestinal problems may also be at risk of developing GERD.

Scientists conducted a large population-based study to assess this bidirectional association between fibromyalgia and GERD, and to determine if patients with either disease have a greater risk of developing the other condition. To do this, patients were compared with healthy individuals. For the analysis, researchers used a nationwide database from the National Health Insurance of Taiwan.

Two study groups were established: The first included 35,117 fibromyalgia patients, and the second included 34,630 GERD patients. Patients were diagnosed between 2000 and 2010. The incidence of GERD in the first group and of fibromyalgia in the second was determined by the end of 2011. Controls had neither disease.

Results showed a bidirectional relationship between the two diseases. The overall incidence of GERD was 1.6-fold greater in the fibromyalgia group than in controls, after controlling for sex, age, comorbidities, and medications. Conversely, the GERD group had a 1.5-fold higher incidence of fibromyalgia than controls.

In addition, data showed that fibromyalgia patients take longer to develop GERD than GERD patients to develop fibromyalgia, which may be associated with the higher prevalence of comorbidities in the GERD group, the team said.

Furthermore, the incidence rates of either disease in the other condition’s group increased with age.

The team believes that among the possible mechanisms in fibromyalgia patients that may explain this association are psychiatric comorbidities, such as depression and anxiety, exhaustion and stress, and the lack of physical exercise, which may lead to mood disorders. In addition, sleep deprivation in GERD, which can exacerbate pain, may be another key factor.

Of note, GERD patients with peptic ulcer disease and those taking nonsteroidal anti-inflammatory drugs (NSAIDs) showed greater risk of developing fibromyalgia. This may be explained by the altered intestinal permeability in these patients.

Overall, “the present study suggests a bidirectional relationship between [fibromyalgia] and GERD,” the authors concluded. “There is a greater risk of developing GERD for [fibromyalgia] patients than developing [fibromyalgia] for GERD patients,” they added.


  1. StevefromMA says:

    So true, discussed last year with my GI. They need to look at the link between sinus problems, GI problems, and FM next.

  2. frances says:

    I have had sinus problems for years…..and severe GI problems along with food intolerance’s ….. Fibromyalgia is now in my family. It’s a bit worrying!

    • Nat says:

      Hi Frances. Nat here. I know how you feel as I have exactly the same problem as you. Except from the sinus problem. But I make up for that on other areas!!. Also. My niece has just been diagnosed with fibro.. And also. My mum got diagnosed with fibro last year. Sending love to you and your family.

  3. Janine Scarisbrick says:

    Studies like these frustrate me. They illustrate connections which sufferers are already convinced exist, but don’t even begin to test the possible reason for the connection. Speculation that it might be because of PIPs / NSAIDs is unhelpful… please someone go test the theory! Studies like this always show avenues for possible research, yet those avenues are never followed up!

  4. I agree with you Janine. I have gerd and fibro.Why can’t they tell us what would help ? They never take it that far. Useless for us.We just continue to suffer. Wonder what the cost of these studies is.I just read that excess mucous can be caused by overgrowth of candida in our system.I suffer with that too. I pray that someone will figure this out,and give us a treatment that works,not just research results.

  5. MIB says:

    The connection has to do with Serotonin and what is coined as “central excitability.” In other words, essentially you feel pain more because of the chemicals in your brain. That is why old school TCAs are effective for migraine, fibro, TMD, etc.

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