Over-the-Counter Painkillers Usually, over-the-counter painkillers aren't particularly effective in treating fibromyalgia-related pain, but they can help when used in combination with other medications. You will need to consult your doctor before taking any over-the-counter medications. Seven things people with fibromyalgia want non-sufferers to know. Fibromyalgia News Today is strictly a news and information website about the disease. It does not provide medical advice, diagnosis or treatment. This content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.