For people with fibromyalgia, pain medication is an important element of managing the disease. As well as dealing with the debilitating pain, medications can also help sufferers with fatigue, muscle spasms, and depression. Before taking any new pain medication, it's important to speak to your health care provider to ensure it's safe for you and won't interfere with any other medications you may be taking. Here are seven of the most common medications used for treating fibromyalgia according to practicalpainmanagement.com: Antidepressants In addition to treating depression, antidepressants can also be used to help block pain signals to the brain. There are two antidepressant drugs which have been approved by the FDA for the treatment of fibromyalgia—duloxetine (Cymbalta) and milnacipran (Savella). Patients can also be prescribed selective serotonin reuptake inhibitors (SSRIs) such as Prozac or Paxil or tricyclic anti-depressants such as Pamelor and Elavil. Could massage help relieve fibromyalgia pain?