Q10 Treatment Improved Psychiatric, Clinical Symptoms in Fibromyalgia Patients

Q10 Treatment Improved Psychiatric, Clinical Symptoms in Fibromyalgia Patients

Treatment with the coenzyme Q10 improved a wide range of psychiatric symptoms in patients with fibromyalgia, according to a new study. The treatment also reduced patients’ clinical symptoms and inflammation.

Based on the results, the researchers may have found a biological explanation for the psychological symptoms associated with the disease, and they suggest that Q10 may offer a psychological and biological therapeutic approach in the same treatment.

The work was recently published in the journal CNS Neuroscience & Therapeutics, titled “Effect of coenzyme Q10 on psychopathological symptoms in fibromyalgia patients.

Psychiatric symptoms in fibromyalgia patients, such as depression and anxiety, are still controversial. According to the National Fibromyalgia & Chronic Pain Association (NFMCPA) there is no connection between depression and fibromyalgia, and fibromyalgia is not a psychiatric disorder. The depression associated with fibromyalgia is believed to result from the pain, sleep deprivation, and dysfunction that patients experience.

A recent study suggested that oxidative stress (a process that causes cell damage) and mitochondrial dysfunction (leading to energy deficiency in cells) may contribute to fibromyalgia symptoms. In addition, Q10 deficiency has been observed in patients with fibromyalgia.

Q10 plays an important role in mitochondrial energy production in the cells, and data has reported improvements of clinical symptoms in fibromyalgia patients treated with Q10, including depression.

The research team wanted to further explore the impact of Q10 in different psychiatric symptoms associated with fibromyalgia and clarify possible biological and clinical mechanisms.

Twenty patients with fibromyalgia were screened for psychological and clinical fibromyalgia symptoms with different questionnaires. Blood samples were also collected. The entire procedure was repeated after 40 days of treatment with Q10 (300 mg/day) or a placebo.

Interestingly, the results showed that the group receiving Q10 showed improvements in all measured psychological symptoms, including depression, anxiety, hostility, somatization (multiple medical symptoms with no apparent cause) and obsessive-compulsive behavior, all related to fibromyalgia.

Important improvements in mitochondrial function and antioxidant gene expression (to neutralize the oxidative stress seen in fibromyalgia) were also observed after Q10 treatment. The team also saw a reduction in inflammation and an improvement in clinical symptoms such as pain and sleep deprivation in patients receiving Q10.

High levels of oxidative stress and mitochondrial dysfunction have been associated with both depression and somatization, as well as with clinical symptoms of fibromyalgia. Therefore, the team suggested that Q10 may simultaneously improve the psychological and biological components of the disease.

“Our study has shown a new perspective about the treatment in patients with [fibromyalgia] using CoQ10,” the team wrote. “Because psychopathological symptoms and psychological distress are highly involved in the pathophysiology of [fibromyalgia] and modulate the perception of the disease from the patients, the effect of CoQ10 in this clinical dimension proposes a biological and psychological approach from the same treatment.”

The researchers also emphasized that additional clinical trials involving more patients should be conducted to confirm these results.


  1. Ruth Szymansky says:

    I was diagnosed with fibromyalgia seven years ago after my doctor tested me for everything related to my symptoms.
    Everyday I am exhausted, my energy levels always run low .
    I have nerve, muscle and bone pain .
    I can’t even remember what street I live on some days .
    This disease has affected every fascist of my daily life .
    It lead to my marriage dissolving after 10 years .
    Some of my children going to live with there father bc fibromyalgia affects everyone your around .
    I have spent thousands on medications, treatments that don’t work , injections that are a waste of time .
    Doctors are saying to be more active that it is good for the pain . Well can someone tell me where that energy is supposed to come from ?
    I’m tired of every stigma that goes along with the disease bc I may not look sick .
    As far as mental aspects go if there is no correlation between depression and anxiety with this illness then why are so many people that suffer from fibromyalgia depressed and overly anxious .
    I want to see more money net put into more research on fibromyalgia and some type of answer . I can’t live the rest of my life like this .

  2. StevefromMA says:

    Thx, interesting. There is an earlier study of 300 qd CoQ10, actually a large dose, for six weeks, that caused a pain reduction in FM. Did not work for me.

  3. Pat Servera says:

    In your opinion from entries that people have written in, which form of CQ10 do people take, pill or liquid? thanks

  4. Maria says:

    Yes this is interesting but needs to be unlocked from a journal so that sufferers can learn more, particularly about dosage. People are in distress now and need more information. Thank you.

  5. Ruth Szymansky says:

    I totally agree that all news about Q10 needs to be available.
    I can’t wait to start using q10 to get some relieve for myself .

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