When you are dealing with a disease or illness, your immune system is compromised, making it easier to pick up germs and bugs. While it's impossible to live in a completely sterile environment, there are ways to try and minimize the amount of germs around your home according to the NHS: 1. Cleaning Materials Mops and buckets should be disinfected after use, and mop-heads replaced regularly. Wherever possible, use disposable cloths or paper towels to clean up spillages. Cloths and sponges that are re-usable need to be disinfected after every use. Discover 10 tips to help you through cold and flu season.