Serotonin Levels Decrease During Pregnancy in Women with Fibromyalgia

Serotonin Levels Decrease During Pregnancy in Women with Fibromyalgia
0
(0)

Levels of the neurotransmitter serotonin are decreased in pregnant women with fibromyalgia, a small study shows.

The study “Lower Serotonin Level and Higher Rate of Fibromyalgia Syndrome with Advancing Pregnancy” was published in The Journal of Maternal-Fetal & Neonatal Medicine.

Serotonin is known to induce a feeling of happiness, vitality and euphoria. Its absence has been associated with depression, tiredness, and a nervous mood. In the brain, serotonin influences cognition, emotion, mood, and behavioral control, among others.

Previous studies have suggested that fibromyalgia may have a negative impact in pregnancy outcomes, but the number of studies examining the relationship between fibromyalgia and pregnancy is still low.

Now, a team of researchers proposed to investigate this possible relationship, and focused on the potential role of serotonin.

Previous work suggested that during pregnancy, serotonin synthesis and the activity declines. Interestingly, other studies have proposed that serotonin impairment in fibromyalgia contributes to the development of the disease.

Researchers performed a prospective case-control study with 277 pregnant women attending the Ankara University Faculty of Medicine, in Turkey, between January and June 2015. A fibromyalgia diagnosis was confirmed using the 2010 ACR diagnostic criteria.

Participants were asked to answer several questionnaires, including the Fibromyalgia Impact Criteria (FIQ), Widespread Pain Index (WPI), Symptom Severity Scale (SS), Beck Depression Inventory and Visual Analog Scale (VAS). In total, 150 pregnant women with a confirmed fibromyalgia diagnosis, and 127 pregnant women without the disease (control group) were evaluated.

Researchers also measured the levels of several markers important for muscle and bone metabolism, including glucose, calcium, phosphorus, parathyroid hormone (PTH), thyroid stimulant hormone (TSH), and the levels of serotonin.

The results showed that fibromyalgia has a negative impact in both physical and physiological parameters in pregnant women. Anxiety and depression were higher in pregnant women with fibromyalgia when compared to those without the disease.

Moreover, researchers found that the levels of serotonin were significantly lower in the fibromyalgia group than in the controls. Researchers also observed that lower levels of serotonin correlated with increased pain and physical limitation.

No differences were found between the groups regarding the levels of glucose, calcium, PTH and TSH.

Overall, the results show that serotonin levels are decreased in women with fibromyalgia, and that these levels are further reduced during pregnancy.

While these findings may suggest that lower serotonin may increase the risk for developing fibromyalgia, researchers found no statistically significant results to confirm this hypothesis.

 

Patricia holds a Ph.D. in Cell Biology from University Nova de Lisboa, and has served as an author on several research projects and fellowships, as well as major grant applications for European Agencies. She has also served as a PhD student research assistant at the Department of Microbiology & Immunology, Columbia University, New York.
×
Patricia holds a Ph.D. in Cell Biology from University Nova de Lisboa, and has served as an author on several research projects and fellowships, as well as major grant applications for European Agencies. She has also served as a PhD student research assistant at the Department of Microbiology & Immunology, Columbia University, New York.
Latest Posts
  • gout treatment
  • stress and cognition
  • TNX-102 SL clinical trial
  • juvenile fibromyalgia and pain

How useful was this post?

Click on a star to rate it!

Average rating 0 / 5. Vote count: 0

No votes so far! Be the first to rate this post.

As you found this post useful...

Follow us on social media!

We are sorry that this post was not useful for you!

Let us improve this post!

Tell us how we can improve this post?