Serotonin Levels Decrease During Pregnancy in Women with Fibromyalgia

Serotonin Levels Decrease During Pregnancy in Women with Fibromyalgia
Levels of the neurotransmitter serotonin are decreased in pregnant women with fibromyalgia, a small study shows. The study “Lower Serotonin Level and Higher Rate of Fibromyalgia Syndrome with Advancing Pregnancy” was published in The Journal of Maternal-Fetal & Neonatal Medicine. Serotonin is known to induce a feeling of happiness, vitality and euphoria. Its absence has been associated with depression, tiredness, and a nervous mood. In the brain, serotonin influences cognition, emotion, mood, and behavioral control, among others. Previous studies have suggested that fibromyalgia may have a negative impact in pregnancy outcomes, but the number of studies examining the relationship between fibromyalgia and pregnancy is still low. Now, a team of researchers proposed to investigate this possible relationship, and focused on the potential role of serotonin. Previous work suggested that during pregnancy, serotonin synthesis and the activity declines. Interestingly, other studies have proposed that serotonin impairment in fibromyalgia contributes to the development of the disease. Researchers performed a prospective case-control study with 277 pregnant women attending the Ankara University Faculty of Medicine, in Turkey, between January and June 2015. A fibromyalgia diagnosis was confirmed using the 2010 ACR diagnostic criteria. Participants were asked to answer several questionnaires, including the Fibromyalgia Impact Criteria (FIQ), Widespread Pain Index (WPI), Symptom Severity Scale (SS), Beck Depression Inventory and Visual Analog Scale (VAS). In total, 150 pregnant women with a confirmed fibromyalgia diagnosis,
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