Melatonin Improves Motor Activity in Rats with Fibromyalgia-Like Disease, Study Shows

Melatonin Improves Motor Activity in Rats with Fibromyalgia-Like Disease, Study Shows
Rats with a fibromyalgia-like disease showed improvements in spontaneous motor activity and other physical changes associated with the disease after treatment with melatonin, the naturally occurring substance that regulates sleep. The study titled, “Oral Supplementation of Melatonin Protects against Fibromyalgia-Related Skeletal Muscle Alterations in Reserpine-Induced Myalgia Rats,” was published in the International Journal of Molecular Sciences. Melatonin is a well-known anti-inflammatory, antioxidant, and analgesic agent. Researchers hypothesized that it also could offer clinical benefits in fibromyalgia. In the study, 90 rats received reserpine, a drug that induces a fibromyalgia-like disease, and then were treated with different doses of melatonin. The frequency with which rats initiated activity on an exercise wheel was then compared among the groups. Results showed that treatment with melatonin improved the animals’ motor activity, with an increase in both the number of times rats ran on the exercise wheel and the distance they covered. This indicates that movement-induced pain was lower in these animals. “Probably, melatoni
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