New Test Accurately Distinguishes Fibromyalgia From Lupus

New Test Accurately Distinguishes Fibromyalgia From Lupus
A recent study found it is possible to distinguish systemic lupus erythematosus (SLE) patients from those with primary fibromyalgia (FM), with complete specificity, using a new test measuring the levels of abundant proteins in circulation. The study, “Systemic lupus erythematosus and primary fibromyalgia can be distinguished by testing for cell-bound complement activation products,” was published in Lupus Science & Medicine. SLE is an autoimmune systemic disease with patients experiencing a variety of symptoms that include chronic pain, arthralgia, fatigue, and morning stiffness. Many, however, present symptoms that are non-specific and not in agreement with the formal criteria established by the American College of Rheumatology. As a result, they may long remain undiagnosed. SLE has been distinguished from other diseases by combining clinical history, demographic information, and age at disease onset with a clinician examination accompanied by laboratory tests looking for antinuclear antibodies (ANA), among other SLE-specific autoantibodies. However, the specificity of this test for SLE is challenged, given that around 14 percent of the general population is also positive for antinuclear antibodies as are, importantly, 15 percent to 25 percent of people with FM. Researchers investigated if a test had already proved more sensitive when compared with anti-DNA antibodies (the standard method for SLE diagnosis), and was an effective strategy for differentiating SLE from primary FM. The test combines cell-bound complement activation products (CB-CAPs) biomarkers (including erythrocyte-C4
Subscribe or to access all post and page content.

Leave a Comment

Your email address will not be published. Required fields are marked *