Vitamin D Levels Associated With Fatigue, Musculoskeletal Pain in Patients With Fibromyalgia

Vitamin D Levels Associated With Fatigue, Musculoskeletal Pain in Patients With Fibromyalgia
Researchers from Seoul presented study results on vitamin D deficiency in patients with rheumatic diseases at the European League Against Rheumatism Annual European Congress of Rheumatology (EULAR) in Rome, June 10-13. The poster entitled: “Vitamin D status and the efficacy of high-dose intramuscular cholecalciferol on musculoskeletal pain and morning fatigue in patients with chronic rheumatic diseases” was presented during the session “Fibromyalgia and pain in rheumatic diseases”. Low levels of vitamin D have been reported in patients with inflammatory rheumatic conditions such as rheumatoid arthritis (RA), osteoarthritis (OA) and fibromyalgia syndrome (FMS). Vitamin D is acquired either from dietary sources of from exposure to ultraviolet B (UVB) radiation, which converts the precursors in the skin into cholecalciferol. In the liver, Vitamin D and cholecalciferol are converted to 25-hydroxyvitamin D (25-OHD), allowing to measure the status of Vitamin D in the organism. In this study researchers determined the association between serum 25-OHD and musculoskeletal pain or morning fatigue in RA, OA and FMS patients. They found that 77.5% of patients with FM had significantly lower levels of vitamin D compared to patients with OA (23.5%) but not to patients with RA (64.4%). They then investigated the efficacy of intramuscular injections of cholecalciferol (every four weeks for three times) to improve the pain and fatigue in those patients with 25-OHD deficiency. They used the Visual analog scale (VAS) to measure musculoskeletal pain and morning fatigue. The patients had to mark on a horizontal line the point that corresponded to their perception of pain and fatigue. Researchers found that VAS for pain and fatigue were significantly decreased in each dise
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