Researchers in Spain have provided the first report that mitochrondria could be affected in fibromyalgia, and may cause problems with the skin and pain in this disease. The study, titled "Oxidative stress, mitochondrial dysfunction and, inflammation common events in skin of patients with Fibromyalgia" appeared in the February 7th issue of Mitochondrion.Fibromyalgia (FM) is characterized by chronic pain, fatigue, sleep, memory and mood disturbances. Women are more often affected than men. Symptoms can start following a physical trauma, significant psychological stress, surgery or illness. In other instances, there is no clear trigger and symptoms increase over time. The cause of this disease is not known, and for many years some physicians have doubted its existence altogether. Recent research indicates that oxidative stress, mitochondrial problems and inflammation could all be behind the cause of the disease. Oxidative stress refers to the production of damaging free-radicals faster than the body is able to de-toxify by removing them. Free radicals are produced by cells in the mitochondria; the power houses of the cells that create energy.