Vitamin D, Antidepressants May Improve Quality of Life in Fibromyalgia Patients, Study Suggests

Vitamin D, Antidepressants May Improve Quality of Life in Fibromyalgia Patients, Study Suggests
Vitamin D-deficient fibromyalgia patients may benefit both physically and psychologically from vitamin D supplements combined with an antidepressant, according to researchers. Their study, "Effects of vitamin D optimization on quality of life of patients with fibromyalgia: A randomized controlled trial," was published in the Medical Journal of the Islamic Republic of Iran. Vitamin D is essential for maintaining the function of the musculoskeletal system, and low levels of this compound have long been proposed to be linked to chronic widespread pain, the primary symptom of fibromyalgia. But there is still no consensus about the association between vitamin D and fibromyalgia. Various studies have demonstrated a positive correlation between low vitamin D levels and nonspecific musculoskeletal pains, while others admit no association at all between fibromyalgia and vitamin D. "To the best of our knowledge, only one published randomized controlled trial is available on the role of vitamin D in the [disease process] of fibromyalgia, which indicates the efficacy of 25-hydroxy vitamin D optimization in [the] reduction of pain and morning fatigue symptoms of the affected patients," researchers from the Iran University of Medical Sciences wrote. A low dose of an antidepressant called trazodone is recommended by the American Pain Society to improve sleep quality in people with fibromyalgia. Because fibromyalgia is a disease with both physi
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