Two Proteins Identified as Potential Markers for Fibromyalgia in Large-Scale Analysis, Study Reports

Two Proteins Identified as Potential Markers for Fibromyalgia in Large-Scale Analysis, Study Reports
Two proteins linked to inflammation and oxidative stress are deregulated in blood samples of fibromyalgia (FM) patients compared with healthy controls, according to findings from a large-scale protein analysis. Specifically, the levels of these two proteins, called haptoglobin and fibrinogen, which respond to inflammation, were found to be increased in fibromyalgia patients and may work as biomarkers for a faster and more timely diagnosis, the researchers suggest. The study, “Insight into the biological pathways underlying fibromyalgia by a proteomic approach,” was published in the Journal of Proteomics. The underlying cause of fibromyalgia, a disease characterized by widespread muscle pain and fatigue, remains unknown; however, several factors are known to contribute to the condition. Among these factors, inflammation and oxidative stress are the most frequently reported. Oxidative stress is caused by an imbalance between the body’s production of potentially harmful reactive oxygen species and its ability to contain them. The complexity of factors contributing to fibromyalgia represent an added difficulty to treatment and even diagnosis of the disease — it can take up to five years for patients to be diagnosed. This highlights the need to find good markers that may assist in identifying fibromyalgia in a more timely manner so that appropriate treatments are administered promptly. In this study, researchers used a technique called proteomics to identify and measure potential changes in proteins in the blood of fibromyalgia pa
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2 comments

  1. Sheryl Barbour says:

    It was 25 yrs ago I had to have surgery for Adult Scolosis. My illness came on me so quick. I had never had pain in my life when this happened I was in so much pain. A Dr in Florida said I had severe Fibromyalgia that there was no where to inject me in my back or neck, would have to do it all. After my 16 hr spine surgery My back pressure points were a little better. I have some much haedware in my spine. the Fibromyalgia is so bad daily. Only thing that helps is massage myofacsial work. It is a hard life I have good days and real bad days also. I got RSD of the left arm and neck from my surgery, Have been on Disabily since 1993. They had to fuse my spine with c rods 14 hooks and 2 cross bars, it is garbage won a law suite they donot make ths hardware anymore. Fused from T-2 to L-4 it is all stainless steeel. Miami had a grant to use it. No one would remove it the risk was to high wellit is way to big for my back. I need to write a Book. Now I have connective tissue problems had organ prolapse and Bladder Had a Vaginal Hyst. and Bladder fixed well the Bladder prolapsed agai 8 months after surgery. Not able to do Pelvic floor Excer. do to my Harware. My muscles just hang in my arms,no muscles in my stomach left. I take one day at a time. Doctors are scared of me. I was in a wheel chair years ago due to Fibro. Thanks for your site. Wish Doctors would pay for massage.

  2. Christine Lynch says:

    Thank you, Patricia, for writing this article. It’s good to know that we fibromites haven’t been forgotten. As long as research continues, hope exists.

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