Biomarkers in Saliva of Fibromyalgia Patients May Be Diagnostic Tool

Biomarkers in Saliva of Fibromyalgia Patients May Be Diagnostic Tool
Researchers have found that increased levels of three proteins in the saliva, namely alpha-enolase, phosphoglycerate mutase 1 and serotransferrin, may help differentiate fibromyalgia (FM) patients from those with other inflammatory diseases. The study with that finding, “Putative salivary biomarkers useful to differentiate patients with fibromyalgia,” was published in the Journal of Proteomics. Researchers investigated whether saliva from FM patients has potential diagnostic and/or prognostic biomarkers that could improve how patients are managed and treated. They performed a proteomics analysis – a strategy to identify all the proteins  – in saliva samples from four groups: an FM group, a group of healthy subjects, one with patients who have rheumatoid arthritis (RA) (model of inflammatory chronic pain), and one group with people suffering migraines (model of non-inflammatory chronic pain). Each group was composed of 30 participants. The RA and migraine groups were added as positive controls, i.e., to ensure that the proteomics analysis was performed correctly. The outcome of the analysis identified 17 protein spots showing a difference of expression (quantity) in FM relative to RA; they also found 19 and 23 protein spots showing differences relative to migraines and healthy subjects, respectively. “In particular, we found 5 spots differentially expressed solely in FM,” researchers wrote. Further analysis identified four of these spots as isoforms – similar proteins, but with a different structure – of a protein called serotransferrin, and one spot bel
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