Sex Hormone Fluctuations Regulate Pain Severity in Women with Fibromyalgia, Study Finds

Sex Hormone Fluctuations Regulate Pain Severity in Women with Fibromyalgia, Study Finds
The severity of fibromyalgia pain was found to be associated with daily fluctuations of progesterone and testosterone hormones, according to the results of a study published in The Journal of Pain. The study is titled “Daily Fluctuations of Progesterone and Testosterone are Associated with Fibromyalgia Pain Severity.” Fibromyalgia is a disease characterized by diffuse chronic pain that can severely impact a person’s ability to perform daily life activities. The disease is more frequent in women, with a female to male incidence ratio of 7:1. A previous study showed that the incidence of pediatric fibromyalgia is similar in both genders until the onset of puberty, after which the disease starts to be more frequent among girls than boys. This disparity raised suspicions of a link between sex hormones and chronic pain. A research team at the University of Alabama at Birmingham conducted a daily evaluation of sex hormone levels for more than 25 consecutive days in eight women diagnosed with fibromyalgia. All women kept daily reports of pain severity. Analysis of estradiol, progesterone, and testosterone levels revealed that all the women analyzed had hormone levels consistent with normal menstrual cycles. Day-to-day changes in both pain and hormone levels revealed that lower levels of progesterone and testosterone were significantly associated with increased pain. Add
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6 comments

  1. Susan Entwistle says:

    Very interesting indeed. I was diagnosed with FM in 2013 and also around same time told by my doc I was post menopausal and have been now for almost 5years. Would be good to know if it is related and part of cause of my FM pain!

  2. Vicky says:

    I was diagnosed in 2001 at 42 years of age. I was told at the time fibromyalgia was not progressive. That has not been my experience. Every year I have felt worse. In 2006 my symptoms left me unable to run my business. In 2012 double pain, fatigue,burning skin and nausea. Full blown menopause hit the same year. Please keep looking for the answers for all our daughters.

    • Danielle says:

      Fibromyalgia and changing, fluctuating hormones are the same in my opinion although so many women don’t agree with me! Same story, premature menopause at age 35 and fibromyalgia symptoms which started a few years before my diagnose. Symptoms fluctuate just like hormones fluctuate. Besides that a long list with other fibro. symptoms due to menopause. I don’t understand the whole medical community! All those scientists with their own subjective ideas and no understanding what women issues are. Doctors are totally clueless and have no idea what changing hormones can do to some women! Life disrupting. We are excluded from most research. It is ridiculous. Doctors must read more on the internet. They only think it is hot flushes, some mood problems and a little bit stiffness. All those hormonal changes, thyroid issues and there effects on nerves, neurotransmitters, brains, muscles, bladder, digestive system, eyes, skin….. can have the exact symptoms like fibromyalgia and cvs.

  3. Anne Grote says:

    Years of lifestyle based restrictions and supplement experiments while researching possible causes for my debilitating tendinitis and adrenal flank pain has just this week finally lead me to looking at the best info I’ve seen correlating my pubescent progesterone deficiency that was treated with Provera to my postmenopausal Fibromyalgia symptoms. It’s becoming apparent to me now that a lifetime of anxiety treated with Bupropion and digestive distress complicated by prolonged NSAID use could have been freaking CURED with a continuance of progesterone therapy. To all of the docs who’ve discredited me for over forty years… Thanks for the lack of advice. I’m going to survive this without you. OTC progesterone cream treatment starts today.

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