Personalized Antidepressant Medication May Help Fibromyalgia Patients Deal with Side Effects, Study Suggests

Personalized Antidepressant Medication May Help Fibromyalgia Patients Deal with Side Effects, Study Suggests
Researchers found that individuals suffering from chronic pain, such as fibromyalgia patients, may tolerate antidepressants’ side effects differently and could benefit from personalized medicine. The results collected from 23 clinical studies conducted over the past two decades were reported in a research article titled “Adverse Effects of Antidepressants for Chronic Pain: A Systematic Review and Meta-analysis,” published in the journal Frontiers in Neurology. Fibromyalgia patients may take low doses of antidepressants to relieve chronic pain and improve sleep. Because the ability to tolerate side effects could be a key to the success of an antidepressant treatment, researchers explored drug-specific adverse effects and individual tolerability to antidepressants. "Understanding adverse effects and their impact on patients' quality of life is crucial in modern clinical medicine and poses a substantial challenge to clinicians who face a exponentially growing range of available medical therapies," Timo Siepmann, the principal investigator of the study, said in a press release. The team performed a meta analysis of the reported adverse effects of commonly used antidepressants. The study included the
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