Resistance Exercise May Improve Pain and Fatigue in Lean Women with FM, Study Shows

Resistance Exercise May Improve Pain and Fatigue in Lean Women with FM, Study Shows
Resistance exercise may improve pain, fatigue, and muscular strength in lean women with fibromyalgia (FM), according to a new study. In overweight and obese women, this type of exercise may improve arm strength. The results were published in the journal BMC Musculoskeletal Disorderstitled “Benefits Of Resistance Exercise in Lean Women With Fibromyalgia: Involvement of IGF-1 and Leptin.” FM is characterized by chronic pain and fatigue, although the exact mechanisms underlying these symptoms remain elusive. Obesity is also more common among FM patients (prevalence between 40-70%) and associated with increased levels of pain. Previous studies have shown that FM symptoms may improve after aerobic exercise, which may involve metabolic factors such as insulin-like growth factor 1 (IGF-1; plays a key role in the adaptation to exercise) and leptin. To investigate metabolic factors in relation to resistance exercise, the study (NCT01226784) enrolled 43 women with FM (ages 20–65) to participate in a program of supervised progressive resistance exercise, two times a week for 15 weeks. Blood samples were collected at the study's start and end to analyze the levels of free and total IGF-1, IGF-binding protein 3 (IGFBP3), adiponectin (a protein that plays a role in insulin resistance), leptin (a hormone that regulates satiety and body weight), and resistin (a hormone that may be involved in obesity, insulin resistance, and diabetes). Pain was assessed with a visual analogue scale; fatigue was rated using the
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