Remeron May Provide Pain Relief in Fibromyalgia, Japanese Study Suggests

Remeron May Provide Pain Relief in Fibromyalgia, Japanese Study Suggests
Mirtazapine (Remeron) may be an effective pain relief treatment for fibromyalgia, according to a study based on the results from a Phase 2a clinical trial based in Japan. Although mirtazapine is generally prescribed as an antidepressant, the trial showed that fibromyalgia patients who don't exhibit symptoms of depression experienced a significant reduction in pain. The study, “Efficacy of mirtazapine for the treatment of fibromyalgia without concomitant depression: a randomized, double-blind, placebo-controlled phase IIa study in Japan,” was published in the journal Pain. Pregabalin (an antiepileptic drug) and duloxetine (a serotonin–noradrenaline reuptake inhibitor) are currently approved fibromyalgia treatments in Japan. Although not by the same mechanism, mirtazapine behaves similarly to serotonin–noradrenaline reuptake inhibitors. Additionally, prior studies have shown the therapy to be effective in decreasing pain, fatigue, and sleep disturbances in fibromyalgia. Researchers in this clinical study sought to determine mirtazapine's effectiveness at a fixed dosage in fibromyalgia patients and, to alleviate potential bias or conflicting effects, the study group excluded p
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