Fibromyalgia Pain Linked to Muscle Metabolites, Reduced by Exercise

Fibromyalgia Pain Linked to Muscle Metabolites, Reduced by Exercise
Exercise may lower the levels of muscle metabolites that can trigger pain in fibromyalgia patients, according to a new study. The study, "Increased Interstitial Concentrations of Glutamate and Pyruvate in Vastus Lateralis of Women with Fibromyalgia Syndrome Are Normalized after an Exercise Intervention - A Case-Control Study," was published in the journal PLOS ONE. But because the normalization of metabolites was not enough to successfully reduce all pain among participants of the study, researchers suggest that fibromyalgia pain results from changes in muscles and communications in the brain. Increasing evidence from previous studies had linked brain and spinal cord neuron signaling to pain in fibromyalgia. Additionally, it has been suggested that muscles hold many factors that could potentially increase pain sensitivity, but few studies had investigated how they muscles relate to the disease. Because exercise is reported to reduce pain in fibromyalgia, researchers at Linköping University in Sweden sought to explore molecular changes that might bring about such improvement. The team recruited 29 women with fibromyalgia and 28 healthy volunteers. Concentrating on the participants' largest thigh muscle, the researchers measured a range of muscle factors using a method called microdialysis, which can measure metabolite levels surrounding muscle cells. Researchers also examined overall body measurements, blood pressure, level of psychological distress, and aspects of quality of life. Additionally, they established the number of tender points, duration of pain, pre
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