Diagnosing Fibromyalgia May Be Possible Using Noninvasive Eye Examination

Diagnosing Fibromyalgia May Be Possible Using Noninvasive Eye Examination

Diagnosing fibromyalgia (FM) can be difficult for clinicians because there is no specific diagnostic test and they often rely on a group of symptoms described by their patients.

Now, in a study titled “Fibromyalgia Is Correlated with Retinal Nerve Fiber Layer Thinning,” published in the journal PloS One, researchers revealed that a noninvasive eye examination can aid in diagnosing fibromyalgia.

Imaging techniques such as MRI can detect neuronal changes in pain-related brain regions of fibromyalgia patients. However, these types of exams are expensive and not always available in clinical practices. This led researchers to investigate visual loss in fibromyalgia patients, since it is a hallmark of neuronal dysfunction easily detected by routine tests.

The research team examined the visual function of 116 fibromyalgia patients and 144 age-matched healthy controls. Researchers used optical coherence tomography (OCT) to measure a layer of nerve fibers that coats the eye, known as the retinal nerve fiber layer (RNFL).

“The ophthalmologic tests described in this study allow for the eye to be utilized as a ‘window’ to the central nervous system, specifically to directly observe the axons in the optic nerve,” the authors wrote in their report.

Ophthalmologists routinely use OCT to diagnose diseases such as glaucoma and diabetic retinopathy because it is noninvasive, inexpensive, fast, and comfortable for the patient. Using this same technique, researchers found a significant decrease in the thickness of RNFL in fibromyalgia patients, even in those with mild fibromyalgia, according to the Fibromyalgia Impact Questionnaire (FIQ).

From the fibromyalgia patients analyzed, OCT distinguished those with biologic fibromyalgia (low depression but high sensitivity to pain), compared to patients suffering from depressive or atypical fibromyalgia.

Future studies with more fibromyalgia patients followed by longer periods will be required to confirm the use of OCT as a diagnostic tool. These studies will also confirm whether OCT can be used to follow disease progression, to identify patients with worse prognoses or at higher risk for loss of quality of life, and to measure treatment effectiveness.

“Obviously, fibromyalgia patients should be diagnosed and followed-up by a rheumatologist, but ophthalmologic tests are new, noninvasive, and cost-effective tools that can be used to facilitate the diagnosis of fibromyalgia and may reduce the expenses associated with diagnosis of this disease,” the authors concluded.

11 comments

  1. Betty Durazo says:

    I was diagnosed with glaucoma just a few months ago. I have had Fibromyalgia for 16 years now. I wonder if these two things are related?

      • Donna Klesmith says:

        If I understand your comment above, “both somewhat common conditions in aging” you are saying fibro is a common condition in aging. I have had FMS since 1980 (my early 20″s), and fibro can be found in children too. So, would you be able to correct the statement, or show the facts that have led you to believe this.

        • Donna Klesmith says:

          Just to clarify, you are saying fibro is a common condition in aging. This syndrome can be found in young adults and children. I have to strongly disagree.

  2. Celia Foster says:

    It took three years to get an appointment with a specialist to be formally diagnosed. I am blessed with a great family doctor who hhas supported me 150%! I’ve had to end my 29 year career doing a job that I love and am now attempting to retrain.

  3. KAREN says:

    I’ve printed this article to take to my Ophthalmologist on Friday! Thanks for sharing. I have had the test in the past to rule out glaucoma. I do not have glaucoma but thick corneas!! 🙂 Thanks for info!

  4. Pat says:

    My glaucoma numbers just went to 22 in each eye .. never had a problem before and also I’ve been having pain behind one eye for several months now. (Sometimes jabbing, but mostly dull pain.) My ophthalmologist says my eyes both look healthy at this point. I was diagnosed with fibro in 1985 & I’m 68 years old now. Is eye pain a symptom any others have had?

  5. Tall Poppy says:

    Fibromyalgia is not an autoimmune connective tissue disease. It falls within the affective spectrum of disorders. Treatment includes aerobic and strengthening exercises, cognitive behavioral therapy, multicomponent therapy, defined physical therapies, acupuncture, hydrotherapy, hypnotherapy, meditative movement therapies such as yoga, tai chi and other stress-reducing therapies. The pharmalogic interventions include low dose amitriptyline (initial 12-lead ECG and yearly repeat required monitoring due to Q-T prolongation), duloxetine/milnacipran, tramadol, pregabalin and cyclobenzaprine. Coordination and implementation of the above falls within the purview of either a psychiatrist or primary care provider.

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