2 Fibromyalgia Therapies Used in Combination Seen in Study to Offer Superior Relief

2 Fibromyalgia Therapies Used in Combination Seen in Study to Offer Superior Relief
A team of researchers at Queens University in Ontario, Canada, report discovering a more effective technique for treating fibromyalgia. Results of a trial led by the scientists suggest that combining Lyrica (pregabalin), an anti-seizure drug, with Cymbalta (duloxetine), an antidepressant — drugs that have been proven, individually, to treat fibromyalgia pain — can safely improve patient outcomes. “Previous evidence supports added benefits with some drug combinations in fibromyalgia,” Dr. Ian Gilron, a professor of Anesthesiology, and Biomedical Sciences, and Director of Clinical Pain Research at the Queen's Centre for Neuroscience Studies, said in a university press release. “We are very excited to present the first evidence demonstrating superiority of a duloxetine-pregabalin combination over either drug alone." The study's findings are published in the current edition of the journal Pain, in the paper "Combination of pregabalin with duloxetine for fibromyalgia: a randomized controlled trial." The investigators explain that their randomized, double-blind, four-period crossover trial compared a pregabalin–duloxetine combination to each drug respectively as a monotherapy. Study participants received maximally tolerated doses of placebo, pregabalin, duloxetine, and the pregabalin–duloxetine combination for six weeks, with results finding that combining pregabalin and duloxetine for fibromyalgia not only provided pain relief, but also improved physical function and overall quality of life. The research team recommends that further research should compare this and other drug combinations to monotherapy for treating fibromyalgia. While fibromyalgia was initially thought to be a musculoskeletal disorder, according to Gilron and his colleagues, r
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