HPA-Axis Dysregulation Modulated by Exercise in Fibromyalgia Patients

HPA-Axis Dysregulation Modulated by Exercise in Fibromyalgia Patients
A study recently published in the Journal of Physical Therapy Science shows evidence of a hypothalamus–pituitary–adrenal (HPA) axis dysregulation in fibromyalgia (FM) patients – a disturbance the team believed is altered by exercise. The study, entitled ”Does aerobic exercise affect the hypothalamic-pituitary-adrenal hormonal response in patients with fibromyalgia syndrome?”  enrolled fifty-six female participants divided into two groups. The first group was instructed to perform daily stretching and flexibility exercises at home, while the second group received group aerobic exercise sessions three times per week, in addition to the stretching exercises. The main aim of the study – performed by Aysun Genc and colleagues at Ankara University, Turkey – was to investigate the levels of growth hormone, insulin-like growth factor (IGF)-1, adrenocorticotropic hormone (ACTH) and cortisol following the different kinds of exercise, which are closely linked to the HPA axis – a hormonal cascade involved in the stress response. An abnormal stress response is characterized by higher than normal levels of cortisol, which, together with decreased levels of growth hormone, are often observed in FM patients. In addition, the team measured the effects of exercise on disease symptoms, sleep patterns, cardiovascular fitness, disability, and health-related quality of life. The measurements of disease-specific symptoms included pain, the number of tender points and morning stiffness duration. Researchers observed that following six w
Subscribe or to access all post and page content.

Leave a Comment

Your email address will not be published. Required fields are marked *