Researchers Compare Twins’ DNA To Discover Fibromyalgia Diagnosis

Researchers Compare Twins’ DNA To Discover Fibromyalgia Diagnosis
Researchers from King’s College London are trying to develop an effective strategy to diagnose fibromyalgia by comparing the DNA of twins in which one has the disease and the other one does not. Fibromyalgia is a pain syndrome that leads to widespread bone and muscle pain, fatigue and sleep disturbances. Its causes are not clear yet, making is very hard to diagnose, manage and treat. For many years doctors were not convinced on the existence of the disease, thinking it could be something conceived by the patient. Currently, there are no blood tests, x-rays or scans that can actually confirm this pain syndrome; however, some blood tests are used to rule out other conditions. Using an Arthritis Research UK fund of £171,000, investigators from King’s College London, are developing a reliable blood test that can support a proper diagnosis. The team will assess samples from 400 twin volunteers (using the Twins UK Bioresource that enrolled 13,000 twins in which one has chronic widespread pain) in the hopes they can identify DNA biomarkers related to the condition. The goal is to compare healthy and affected twin's DNA to understand fundamental genetic differences. “Currently there is no blood test for fibromyalgia which makes diagnosis difficult and treatment is limited, and in many cases unsatisfactory," said lead researcher Frances Williams,from the Department of Twin Research & Genetic Epidemiology. “Our research will help patients in two ways. First it will contribute to our understanding of
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