Researchers Discover Altered Gray and White Matter in Fibromyalgia Patients’ Brains

Researchers Discover Altered Gray and White Matter in Fibromyalgia Patients’ Brains
shutterstock_247698262Findings from a recent study published in the journal NeuroImage: Clinical showed that altered gray and white matter morphometry in cerebellar and frontal cortical regions may contribute to, or result from, pain-relevant dysfunction in patients with Fibromyalgia (FM). Chronic pain is a key symptom of patients suffering from FM. This functional pain disorder is characterized by altered resting functional connectivity, associated with spontaneous pain intensity, and which can be normalized following longitudinal therapy. FM also exhibits decreased gray matter volume in the medial frontal gyri and increased gray matter volume in cerebellum. Altered white matter microstructure in FM has been noted with DTI in the thalamus and post central gyrus. Advances in non-invasive structural neuroimaging, including voxel-based morphometry (VBM), diffusion tensor imaging (DTI), and surface-based cortical thickness analyses, have been used to investigate altered brain structure associated with several conditions. In order to provide a detailed analysis of brain structural connectomics in FM patients suffering from chronic pain, in their study titled
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