Vitamin D May Help FMS Patients’ Pain and Fatigue

Vitamin D May Help FMS Patients’ Pain and Fatigue
Chronic pain and fatigue, typical symptoms of fibromyalgia syndrome (FMS), may be treated with vitamin D supplements as an alternative or adjunct to other treatment, as found by researchers working at the Orthopaedic Hospital Speising in Vienna, Austria, whose study results were recently published in the Pain journal. Patients with FMS often have low vitamin D levels, leading to pain and fatigue, and the supplements are not only an alternative to treating the symptoms, but are also cost-effective. The study, "Effects of vitamin D on patients with fibromyalgia syndrome: a randomized placebo-controlled trial" focused on cacifediol, a pre-hormone developed by the cholecalciferol enzyme (vitamin D3) in the liver, which is converted to calcitriol and is the active form of vitamin D. Its concentration in the blood is thought suggest vitamin D levels, and researchers aimed to determine if higher levels would influence the pain in FMS patients. "Low blood levels of calcifediol are especially common in patients with severe pain and fibromyalgia. But although the role of calcifediol in the perception of chronic pain is a widely discussed subject, we lack clear evidence of the role of vitamin D supplementation in fibromyalgia patients," explained the lead investigator Florian Wepner, MD, of the Department of Orthopaedic Pain Management, Spine Unit, Orthopaedic Hospital Speising, in a press release. "We therefore set out to determine whether raising the calcifediol levels in these patients would alleviate pain and cause a general improvement in concomitant disorders." The research team conducted a randomized controlled trial with 30 FMS female patients who registered low serum calcifediol levels. While the participants had blood levels of calcifediol below the 32
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